EQVAMEC P 6ml PER CAVALLI (FOR HORSES)
DescriptionCOMPOSITIONEach ml of paste contains:Ivermectin ……………………… ......................... 20 mgexcipients:Methyl parahydroxybenzoate .. ……… .....................… 1.8 mgPropyl parahydroxybenzoate ...................................... 0.2 mg PHARMACOTHERAPEUTIC ACTIONEQVAMEC-P, through its active component - ivermectin, acts on both endoparasites (nematodes) and ectoparasites in horses. Ivermectin is a derivative of avermectin, isolated from the product obtained by fermenting an actinomycete called Streptomyces avermitilis. In nematodes, ivermectin stimulates the development of GABA (gamma aminobutyric acid) from the neuronal synapse and intensifies the connection of GABA to special receptors, thus interrupting the transmission of nerve influx to nerve junctions, paralyzing and killing the parasite. In arthropods, the interruption of nerve influx occurs at the level of the neuromuscular synapse. This leads to paralysis and death of the parasite. TARGET SPECIESHorses. IndicationsEQVAMEC-P paste, administered in the recommended dose acts against the following:A. Nematodes present in:- stomach: Habronema spp .; Trichostrongylus axei- intestin subtire: Parascaris equorum, Strongyloides westeri- large intestine: Strongylus vulgaris, Strongylus edentatus, Strongylus equinus, Triodontophorus spp., Cyathostomum spp., Oxyurus equi- lung: Dictyocaulus arnfieldi- mosses and skin: Habronema spp., Onchocerca spp.B.Arthropod: Gasterophilus spp.C. Mites: Sarcoptes, Psoroptes, ChorioptesIn special cases, treatment with EQVAMEC-P does not preclude the application, in parallel, of appropriate local therapy for severe wounds caused by skin parasites. All horses in the herd must be included in a regular and strict deworming program with an increased attention to mares, young horses and foals. The foals should be treated initially at the age of 6 to 8 weeks. Regular treatments will reduce the chances of vermin arteritis and colic caused by Strongylus vulgaris. DOSAGE, ROUTE AND METHOD OF ADMINISTRATIONIt is administered by the.The dose of EQVAMEC-P paste is: 1 ml paste / 100 kg g.c., respectively a graduation of the piston of the dosing syringe / 100 kg g.c. (20 mg ivermectin / 100 kg g.c.). The contents of the syringe are sufficient to treat 600 kg g.c. The syringe is inserted into the horse's oral cavity, in the interdental space, as deep as possible, depositing the medicine at the base of the tongue. Immediately after administration, the animal's head is raised for a few seconds. Before administering the paste, care must be taken that there is no fodder in the oral cavity.If the animals do not show an improvement in their health, they will consult a veterinarian to re-evaluate the diagnosis. CONTRAINDICATIONS, PRECAUTIONS AND ADVERSE REACTIONSDo not administer to foals less than 6 weeks. EQVAMEC-P should not be used in other animal species.Do not administer in case of hypersensitivity to the active substance or to any of the excipients. Special attention will be paid to pregnant animals and animals stressed due to malnutrition, unfavorable weather conditions, parking in the pen, etc.The recommended doses have a very wide margin of protection in animals. Following administration of the product to horses massively infested with Onchocerca microfilariae, edema and pruritus may occur due to the death of a large number of microfilariae. In case of prolonged administration, irreversible disturbances of the sense of balance may occur. It can be used during pregnancy or lactation. In horses, oral administration of a dose of 1.8 mg / kg (respectively 9 x the recommended dose) did not produce any symptoms of toxicity, but administration of 2 mg / kg showed visual disturbances, depression and ataxia.No specific antidote is known. In case of intoxication, symptomatic treatment is instituted. WAITING TIMEMeat: 28 days. STORAGE CONDITIONSStore below 25 ° C. Protect yourself from direct light. Avoid frost. METHOD OF PRESENTATION6 ml syringes. .