CARDALIS 10 MG / 80 MG - 30 TABLETS dogs
Cardalis 10 mg / 80 mg - is a brown, palatable tablet with an elongated shape and a midline, used to treat congestive heart failure. Manufacturer: Ceva SanteDCI: Benazepril / Benazeprilum HCI, Spironolactone / Spironolacton NAME OF THE VETERINARY MEDICINAL PRODUCT Cardalis 10mg./ 80mg. tablets for dogs. Benazepril hydrochloric acid 10mg. spironolactone 80mg. DECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS (INGREDIENTS): Cardalis is a brown, palatable oral tablet with an elongated shape and a midline. Benazepril hydrochloride (HCL) (benazeprilum HCL) spironolactone (Spironolactonum) Cardalis 10 mg./80mg. tablets for dogs. Indications For the treatment of congestive heart failure caused by chronic valvular degeneration in dogs (with diuretic support when necessary). CONTRAINDICATIONS Do not administer during pregnancy and lactation. Do not administer to animals used in breeding or those intended to be used for breeding. Do not use in dogs suffering from hypoadenocorticism, hyperkalemia or hyponatremia. Do not use in combination with non-steroidal anti-inflammatory drugs (NSAIDs) in dogs with renal impairment. Do not use in case of hypersensitivity to Angiotensin Converting Enzyme inhibitors (ACE inhibitors) or to any of the excipients. Do not use in case of heart failure caused by aortic or pulmonary stenosis. SIDE EFFECTS: In male dogs treated with spironolactone, reversible prostate atrophy is common. TARGET SPECIES: Dogs. DOSAGE FOR EACH SPECIES, ROUTE (S) OF ADMINISTRATION AND METHOD OF ADMINISTRATION: This combination of active substances of the product should be used only in dogs that require both active substances to be administered concomitantly at this fixed dose. Oral administration. Cardalis tablets should be taken once daily at a dosage of 2 mg. spironolactone per kg. live weight and 0.25 mg./kg. live weight benazepril hydrochloride (HCL), according to the table below. Benazepril hydrochloride (HCL) (benazeprilum HCL) spironolactone (Spironolactonum) Cardalis 2.5 mg./20mg. 2.5mg tablets for dogs. 20mg.Cardalis 5 mg./40 mg. tablets for dogs 5mg. 40mg.Cardalis 10mg./80 mg. tablets for dogs 10mg. 80mg. RECOMMENDATIONS FOR CORRECT ADMINISTRATION:The product should be administered with food. The tablet can be mixed with a small amount of food and given before the main meal or in food. The tablets are flavored. SPECIAL WARNINGS: Special precautions for use in animals. Prior to initiating treatment with spironolactone and benazepril HCL, an assessment of kidney function and serum potassium should be performed, especially in elderly dogs who may suffer from hypoadrenocorticism, hyperkalemia or hyponatraemia. Unlike humans, no increase in the incidence of hyperkalemia has been observed in dogs in clinical trials with this combination. However, regular monitoring of renal function and serum potassium is recommended in dogs with renal impairment, as they are at increased risk for hyperkalemia during treatment with this product. Spironolactone has an antiandrogenic effect and therefore the product is not recommended for growing dogs. As spironolactone undergoes hepatic biotransformation, the product should be administered with caution to dogs with hepatic impairment. Overdose: After administration of a dose 10 times the recommended dosage (20 mg / kg.g.v.spironolactone and 2.5 mg./kg.g.v.benazepril HCL) in healthy dogs, dose-dependent side effects have been reported. Daily administration to healthy dogs of an overdose e.g. 6 times higher (12 mg. / kg. live weight spironolactone and 1.5 mg./kg. live weight benazepril HCL) and 10 times higher (20 mg./kg gvspironolactone and 2.5 mg./ kg.gv benazepril HCL) than the therapeutic dose led to a reduction in red cell mass. However, this decrease is transient, the mass of red blood cells remaining at normal values, the finding was not considered clinically important. A moderate compensatory physiological hypertrophy of the glomerular area of the adrenal glands was found to be dose-dependent. This hypertrophy does not appear to have pathological implications because it is reversible upon cessation of treatment. In case of accidental ingestion by the dog of a large number of Cardalis tablets there is no specific antidote or treatment, it is recommended to induce vomiting, gastric lavage (after risk assessment) and electrolyte monitoring. Symptomatic treatment, rehydration should be performed. OTHER INFORMATION: Package size: The bottles are provided with secure locking system for children. The tablets are packed in bottles of 30 tablets, or 90 tablets in a carton. Not all packaging sizes can be marketed. Important: Cardalis 10 mg / 80 mg - 30 Tablets falls into the category of veterinary pharmacy. Consult your veterinarian for diagnosis, prescription medication or diet according to the specific needs of your dog (cat).